Kambo is a traditional healing ritual used mainly in South America, particularly in communities that live in the Amazon rainforest. It involves the application of a poisonous secretion from the skin of the giant monkey frog, also known as Phyllomedusa bicolor, to small burns on the skin. The secretion contains bioactive peptides that reportedly have therapeutic properties, including pain relief, immunity boosting, treatment of infections, and detoxification. Kambo rituals are typically conducted by experienced practitioners, and are considered sacred by many communities. However, the use of kambo also carries risks, including adverse reactions to the venom, and the spread of infectious diseases due to poor hygiene practices during the ritual.